Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472354 | 0.88 | IGF1R (0.36) | IGF1R | |
| SCHEMBL4464010 | 0.86 | IGF1R (0.40) | IGF1R | |
| SCHEMBL4466081 | 0.81 | DRD2 (0.41) | IGF1RHPGDTSHRNPSR1KMT2A | |
| SCHEMBL4466158 | 0.79 | VHL (0.34) | MEN1KMT2A | |
| SCHEMBL4461041 | 0.72 | IGF1R (0.42) | IGF1RTSHRMEN1KMT2AMAPK1 | |
| SCHEMBL18942317 | 0.63 | LMNA (0.53) | — | |
| SCHEMBL4469777 | 0.59 | CRHBP (0.36) | CRHBPCRHR2HPGDTSHRNPSR1 | |
| SCHEMBL19027124 | 0.57 | GAA (0.40) | CRHBPCRHR2GAAMEN1KMT2A | |
| SCHEMBL2914177 | 0.56 | LGMN (0.35) | CRHBPCRHR2GAAMEN1KMT2A | |
| SCHEMBL17918652 | 0.54 | ALDH1A1 (0.45) | CRHBPCRHR2HPGDNPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |