Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466158 | 0.79 | VHL (0.34) | VHLMEN1KMT2AALDH1A1 | |
| SCHEMBL4471687 | 0.70 | IGF1R (0.38) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2120996 | 0.61 | — | — | |
| SCHEMBL805042 | 0.60 | — | — | |
| SCHEMBL803419 | 0.60 | MEN1 (0.46) | VHLMEN1KMT2AALDH1A1 | |
| SCHEMBL933778 | 0.59 | — | — | |
| SCHEMBL513694 | 0.59 | MEN1 (0.48) | VHLMEN1KMT2AALDH1A1 | |
| SCHEMBL2093209 | 0.59 | — | — | |
| SCHEMBL22792608 | 0.59 | — | — | |
| SCHEMBL15200484 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |