Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172883 | 0.80 | NOTUM (0.41) | NOTUMALOX15MAPK1HSD17B10LMNA | |
| SCHEMBL2422800 | 0.79 | NOTUM (0.40) | NOTUMMAPK1MEN1KMT2AMAPT | |
| SCHEMBL6526654 | 0.74 | NOTUM (0.42) | NOTUMCHRNA7CYP3A4ALOX15CHRNB2 | |
| SCHEMBL2094438 | 0.72 | MAPK1 (0.45) | NOTUMCHRNA7CYP3A4ALOX15CHRNB2 | |
| SCHEMBL9046550 | 0.71 | SLC2A1 (0.40) | CHRNA7ALOX15HSD17B10DRD2DRD3 | |
| SCHEMBL2172788 | 0.71 | ADAM10 (0.43) | NOTUMCYP3A4MAPK1HSD17B10LMNA | |
| SCHEMBL16719407 | 0.70 | MCHR1 (0.56) | NOTUMDRD2HTR3AMBTD1L3MBTL3 | |
| SCHEMBL13174962 | 0.70 | MCHR1 (0.56) | NOTUMDRD2HTR3AMBTD1L3MBTL3 | |
| SCHEMBL27752850 | 0.70 | MCHR1 (0.56) | NOTUMDRD2HTR3AMBTD1L3MBTL3 | |
| SCHEMBL2176945 | 0.70 | L3MBTL3 (0.45) | NOTUMCHRNA7CYP3A4ALOX15CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853243-B2 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORPORATION (US) | 2014-10-07 | — | — | US | disclosed |
| US-7491724-B2 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORPORATION (US) | 2009-02-17 | — | — | US | disclosed |
| US-4148895-A | HYPOTENSIVE, ANTIARRHYMIA AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-04-10 | — | — | US | disclosed |