Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 3/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654063 | 0.92 | OPRM1 (0.38) | DRD2OPRM1OPRL1CCR1ADRA2A | |
| SCHEMBL654382 | 0.90 | DRD2 (0.35) | DRD2OPRM1OPRL1CCR1TMEM97 | |
| SCHEMBL655037 | 0.90 | DRD2 (0.38) | DRD2OPRM1OPRL1CCR1SIGMAR1 | |
| SCHEMBL654871 | 0.90 | DRD2 (0.36) | DRD2CCR1ADRA1A | |
| SCHEMBL655209 | 0.89 | DRD2 (0.34) | DRD2OPRM1OPRL1CCR1TMEM97 | |
| SCHEMBL655822 | 0.89 | DRD2 (0.35) | DRD2OPRM1OPRL1CCR1ADRA1A | |
| SCHEMBL653963 | 0.88 | DRD2 (0.37) | DRD2OPRM1OPRL1CCR1DRD4 | |
| SCHEMBL655073 | 0.88 | CCR1 (0.37) | DRD2OPRM1OPRL1CCR1TMEM97 | |
| SCHEMBL658798 | 0.88 | CCR1 (0.35) | DRD2OPRM1OPRL1CCR1SIGMAR1 | |
| SCHEMBL653148 | 0.88 | DRD2 (0.38) | DRD2OPRM1OPRL1CCR1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |