Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19532369 | 0.83 | GLRA1 (0.49) | GLRA1LMNAHPGDMAPTSMN1; SMN2 | |
| SCHEMBL6476026 | 0.76 | SGMS2 (0.52) | GLRA1LMNAHPGDPTGER1MAPT | |
| SCHEMBL382283 | 0.76 | GLRA1 (0.60) | GLRA1MRGPRX4PTGER1FOLH1MCL1 | |
| SCHEMBL382849 | 0.76 | FOLH1 (0.62) | GLRA1KDM4EMRGPRX4PTGER1FOLH1 | |
| SCHEMBL6391576 | 0.76 | MCL1 (0.56) | GLRA1KDM4EMRGPRX4PTGER1FOLH1 | |
| SCHEMBL6915900 | 0.75 | GLRA1 (0.59) | GLRA1LMNAHPGDMRGPRX4MAPT | |
| SCHEMBL19894409 | 0.75 | GLRA1 (0.49) | GLRA1KDM4ELMNAHPGDPTPN1 | |
| SCHEMBL514495 | 0.75 | GLRA1 (0.65) | GLRA1KDM4ELMNAHPGDTHRA | |
| SCHEMBL13932500 | 0.75 | GLRA1 (0.65) | GLRA1KDM4ELMNAHPGDTHRA | |
| SCHEMBL16860708 | 0.75 | GLRA1 (0.51) | GLRA1KDM4EHPGDPTGER1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073804-A2 | HYDROXY-SUBSTITUTED BENZOIC ACID AMIDE COMPOUNDS FOR USE IN THERAPY | Astex Therapeutics Limited (GB) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008044054-A2 | HYDROXY-SUBSTITUTED BENZOIC ACID AMIDE COMPOUNDS FOR USE IN THERAPY | ASTEX THERAPEUTICS LIMITED (GB) | 2008-04-17 | — | — | WO | disclosed |