⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL322359 | 0.97 | — | — | |
| SCHEMBL2911527 | 0.87 | — | — | |
| SCHEMBL29333213 | 0.87 | GBA1 (0.39) | — | |
| SCHEMBL28109472 | 0.87 | — | — | |
| SCHEMBL6377016 | 0.87 | GBA1 (0.39) | — | |
| SCHEMBL23997512 | 0.86 | GBA1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL6371151 | 0.84 | GBA1 (0.37) | — | |
| SCHEMBL12712292 | 0.84 | GBA1 (0.32) | — | |
| Acetic Acid SCHEMBL72856 | 0.84 | SLC6A1 (0.40) | — | |
| SCHEMBL27691081 | 0.80 | ALDH1A1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 965 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114507227-B | Benzisothiazole compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-06-21 | — | — | CN | claimed |
| CN-114292270-B | BTK inhibitor and preparation method and application thereof | 南方医科大学 | 2023-05-05 | — | — | CN | claimed |
| CN-114591318-A | Pyrazolo heterocyclic compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-06-07 | — | — | CN | claimed |
| WO-2022105782-A1 | BENZISOTHIAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 中国医学科学院药物研究所 | 2022-05-27 | — | — | WO | claimed |
| CN-114507243-A | Isothiazole heterocyclic compound, preparation method thereof, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-05-17 | — | — | CN | claimed |
| CN-114507227-A | Benzisothiazole compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-05-17 | — | — | CN | claimed |
| CN-114292270-A | BTK inhibitor and preparation method and application thereof | 南方医科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-109135198-A | A kind of resin button and preparation method thereof | 罗顺旺 | 2019-01-04 | — | — | CN | claimed |
| CN-107922338-A | The pyridine and application method being substituted | 艾伯维公司 | 2018-04-17 | — | — | CN | claimed |
| CN-107454902-A | Chromene derivative as the kinase inhibitor of phosphoinositide 3 | 奇斯药制品公司 | 2017-12-08 | — | — | CN | claimed |
| US-20020147198-A1 | Substituted arylamine derivatives and methods of use | AMGEN INC. | 2002-10-10 | — | — | US | claimed |
| WO-2002068406-A2 | SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS | AMGEN INC. (US) | 2002-09-06 | — | — | WO | claimed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | claimed |
| WO-2002055501-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMGEN INC (US) | 2002-07-18 | — | — | WO | claimed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | claimed |
| EP-0190786-B1 | AZETIDINE DERIVATIVES; PROCESS FOR THEIR PREPARATION; AND THEIR USE AS INTERMEDIATES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-04-04 | — | — | EP | claimed |
| US-4778577-A | OXIDATION OF ALCOHOL TO ACID WITH NICKEL/III/COMPOUND | SHELL OIL COMPANY (US) | 1988-10-18 | — | — | US | claimed |
| CN-86102422-A | The method for preparing azetidine derivatives | — | 1987-01-28 | — | — | CN | claimed |
| EP-0199413-A2 | Process for preparing azetidine derivatives and novel intermediates therein | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1986-10-29 | — | — | EP | claimed |
| EP-0190786-A1 | Azetidine derivatives; process for their preparation; and their use as intermediates | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1986-08-13 | — | — | EP | claimed |