Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.63 |
| ▸ | METAP1 | P53582 | 3/20 | 0.61 |
| ▸ | PDE5A | O76074 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062754 | 0.87 | ABCG2 (0.65) | KMT2AMEN1PDE5AABCG2MAPT | |
| SCHEMBL1083871 | 0.83 | MEN1 (0.71) | KMT2AMEN1L3MBTL1MAPTNPSR1 | |
| SCHEMBL2912538 | 0.83 | ABCG2 (0.68) | KMT2ARAB9AMEN1NPC1ADORA3 | |
| SCHEMBL2913682 | 0.81 | ABCG2 (0.69) | KMT2ARAB9AMEN1NPC1ADORA3 | |
| SCHEMBL10709371 | 0.78 | KMT2A (0.63) | KMT2ARAB9AMEN1NPC1ADORA3 | |
| SCHEMBL9937654 | 0.78 | ABCG2 (0.77) | KMT2ARAB9AMEN1NPC1METAP1 | |
| SCHEMBL2908125 | 0.77 | KMT2A (1.00) | KMT2ARAB9AMEN1NPC1ADORA3 | |
| SCHEMBL10708288 | 0.77 | ADORA3 (1.00) | KMT2ARAB9AMEN1NPC1ADORA3 | |
| SCHEMBL10706986 | 0.77 | ADORA3 (0.71) | KMT2ARAB9AMEN1NPC1ADORA3 | |
| SCHEMBL10705748 | 0.76 | ADORA3 (0.78) | KMT2ARAB9AMEN1NPC1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560464-B2 | Polycyclic pyrimidines as potassium ion channel modulators | ICAGEN, INC. (US) | 2009-07-14 | — | — | US | disclosed |
| US-20050267089-A1 | Polycyclic pyrimidines as potassium ion channel modulators | ICAGEN, INC. (US) | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267089-A1 | Polycyclic pyrimidines as potassium ion channel modulators | KCNJ2, KCNJ1, KCNJ11 | KMT2A 908/4885RAB9A 3914/4885MEN1 3752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.