Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837693 | 0.79 | ADRA2C (0.57) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL3570064 | 0.78 | ADRA2C (0.64) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2419551 | 0.74 | ALDH1A1 (0.59) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2415540 | 0.74 | ADRA2C (0.41) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2421577 | 0.74 | CNR1 (0.44) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2416816 | 0.73 | ALDH1A1 (0.55) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2418781 | 0.73 | ALDH1A1 (0.55) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL1266343 | 0.73 | ALDH1A1 (0.52) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2422709 | 0.72 | ALDH1A1 (0.59) | ADRA2CKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2421945 | 0.72 | ADRA2C (0.52) | ADRA2CKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625900-B2 | Sutstituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain | GRUENENTHAL GMBH (DE) | 2009-12-01 | — | — | US | claimed |