Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL15173183 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL447074 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL28025182 | 0.97 | CA4 (0.90) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL2235356 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL715802 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL29775 | 0.97 | CA4 (0.89) | CA4CASP1ALDH1A1 | |
| Citric Acid SCHEMBL276988 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL3657 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL8845344 | 0.97 | CA4 (0.89) | CA4CASP1ALDH1A1 | |
| Citric Acid SCHEMBL11060179 | 0.97 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108002840-A | A kind of biology implantation ceramic material and preparation method | 明光市裕阳新材料有限公司 | 2018-05-08 | — | — | CN | claimed |
| WO-2000077242-A2 | DETECTION OF MICROORGANISMS | INTERNATIONAL DIAGNOSTICS GROUP PLC (GB) | 2000-12-21 | — | — | WO | claimed |
| JP-8040975-A | — | — | None | — | — | JP | disclosed |
| CN-111134334-B | Probiotics microcapsule soft particles and preparation method thereof | 内蒙古蒙牛乳业（集团）股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| US-20220395466-A1 | MICROCAPSULE, PREPARATION METHOD AND APPLICATION THEREOF | Inner Mongolia Mengniu Dairy (group) Co., Ltd. (CN) | 2022-12-15 | — | — | US | disclosed |
| EP-4042881-A1 | MICROCAPSULE, PREPARATION METHOD AND APPLICATION THEREOF | INNER MONGOLIA MENGNIU DAIRY (GROUP) CO., LTD. (CN) | 2022-08-17 | — | — | EP | disclosed |
| US-11272725-B2 | Low methoxyl pectin from jelly fig and method for producing the same | HOU SHIH KUO (TW) | 2022-03-15 | — | — | US | disclosed |
| US-20210068435-A1 | LOW METHOXYL PECTIN FROM JELLY FIG AND METHOD FOR PRODUCING THE SAME | HOU SHIH KUO (TW) | 2021-03-11 | — | — | US | disclosed |
| CN-109430251-A | A kind of store method of the preservation liquid of adipose tissue and preparation method thereof with adipose tissue | 广州康琪莱生物科技有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-108002840-A | A kind of biology implantation ceramic material and preparation method | 明光市裕阳新材料有限公司 | 2018-05-08 | — | — | CN | disclosed |
| CN-108002840-A | A kind of biology implantation ceramic material and preparation method | 明光市裕阳新材料有限公司 | 2018-05-08 | — | — | CN | disclosed |
| EP-1429630-A1 | PROCESS FOR THE FORTIFICATION OF A FRUIT BASED FOOD PRODUCT WITH CALCIUM | Purac Biochem B.V. (NL) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003024250-A1 | PROCESS FOR THE FORTIFICATION OF A FRUIT BASED FOOD PRODUCT WITH CALCIUM | PURAC BIOCHEM B.V. (NL) | 2003-03-27 | — | — | WO | disclosed |
| US-20030059499-A1 | Process for the fortification of a fruit based food product with calcium | PURAC BIOCHEM B.V. (NL) | 2003-03-27 | — | — | US | disclosed |
| EP-1295536-A1 | Process for the fortification of a fruit based food product with calcium | Purac Biochem B.V. (NL) | 2003-03-26 | — | — | EP | disclosed |
| CN-1345925-A | Method for preventing non-biological haze and settling in yellow rice wine and clear wine | WANG MEIZHI (CN) | 2002-04-24 | — | — | CN | disclosed |
| CN-1323881-A | Method of preventing non-biogenic turbidity and precipitate in yellow wine | WANG MEIZHI (CN) | 2001-11-28 | — | — | CN | disclosed |
| CN-1323882-A | Method of preventing non-biogenic turbidity and precipitate in yellow wine | WANG MEIZHI (CN) | 2001-11-28 | — | — | CN | disclosed |
| JP-H0840975-A | CALCIUM-ALKALI METAL CITRIC SALT COMPOUND, ITS PRODUCTION AND MEDICINE CONTAINING THE SAME | MADAUS AG | 1996-02-13 | — | — | JP | disclosed |
| US-4170590-A | Ion exchanger treatment of citrate-stabilized plasma | BIOTEST-SERUM-INSTITUT GMBH (DE) | 1979-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220395466-A1 | MICROCAPSULE, PREPARATION METHOD AND APPLICATION THEREOF | CEL, MBOAT4, MLN | CA4 1514/4885CASP1 314/4885FFAR3 1878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.