Indole

Indole

SCHEMBL4470813

c1ccc2[nH]ccc2c1.c1ccc2[nH]ncc2c1

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 2/20 0.73
HSP90AA1 P07900 1/20 0.73
IDO1 P14902 1/20 0.73
TRPA1 O75762 3/20 0.65
CA1 P00915 1/20 0.65
CA2 P00918 1/20 0.65
ITGB2 P05107 1/20 0.65
ICAM1 P05362 1/20 0.65
ITGAL P20701 1/20 0.65
CA4 P22748 1/20 0.65
CA6 P23280 1/20 0.65
AHR P35869 1/20 0.65
ADK P55263 1/20 0.65
ABCB1 P08183 1/20 0.63
PIK3CD O00329 1/20 0.49
PIK3CB P42338 1/20 0.49
DYRK1A Q13627 4/20 0.44
FGFR1 P11362 2/20 0.44
DYRK3 O43781 2/20 0.44
CLK2 P49760 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indazole SCHEMBL29355507 0.85
Indazole SCHEMBL6295 0.85
Indazole SCHEMBL1221882 0.85 HSP90AA1 (1.00) CDK2HSP90AA1IDO1TRPA1ABCB1
Indazole SCHEMBL110751 0.83 HSP90AA1 (0.95) CDK2HSP90AA1IDO1TRPA1ABCB1
Indazole SCHEMBL21058156 0.83 HSP90AA1 (0.95) CDK2HSP90AA1IDO1TRPA1ABCB1
Indazole SCHEMBL5221603 0.83 HSP90AA1 (0.95) CDK2HSP90AA1IDO1TRPA1ABCB1
Indazole SCHEMBL3540508 0.83 HSP90AA1 (0.95) CDK2HSP90AA1IDO1TRPA1ABCB1
Indazole SCHEMBL7371212 0.83 HSP90AA1 (0.95) CDK2HSP90AA1IDO1TRPA1ABCB1
Indazole SCHEMBL9407408 0.83 HSP90AA1 (0.95) CDK2HSP90AA1IDO1TRPA1ABCB1
Indazole SCHEMBL5420749 0.83 HSP90AA1 (0.95) CDK2HSP90AA1IDO1TRPA1ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115611798-B PH trigger charge reversible fluorescent probe and application thereof in cell imaging 齐鲁工业大学 2024-06-14 CN disclosed
CN-104758703-A Medicine for treating primary dysmenorrhea REN HONGXIA 2015-07-08 CN disclosed
CN-104173918-A Traditional Chinese medicinal composition for treating primary dysmenorrhea LU LEI 2014-12-03 CN disclosed
US-7576161-B2 Process for preparing terminally functionalized living and quasiliving cationic telechelic polymers CHEVRON ORONITE COMPANY LLC (US) 2009-08-18 US disclosed
CN-101278872-A Nano memory alloy intrauterine device LIAONING AIMU MEDICAL SCIENCE (CN) 2008-10-08 CN disclosed
WO-2007037540-A1 CELLULOSE ACYLATE FILM, METHOD FOR PRODUCING SAME, OPTICALLY COMPENSATORY FILM, ANTI-REFLECTION FILM, POLARIZING PLATE AND IMAGE DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2007-04-05 WO disclosed
US-20060063762-A1 Indole indazole and benzazole derivative DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2006-03-23 US disclosed
US-20050282972-A1 Process for preparing terminally functionalized living and quasiliving cationic telechelic polymers STOKES CASEY D 2005-12-22 US disclosed
US-6969744-B2 Living and quasiliving cationic telechelic polymers quenched by N-substituted pyrrole and methods for their preparation UNIVERSITY OF SOUTHERN MISSISSIPPI (US) 2005-11-29 US disclosed
US-20040260033-A1 Living and quasiliving cationic telechelic polymers quenched by N-substituted pyrrole and methods for their preparation UNIVERSITY OF SOUTHERN MISSISSIPPI 2004-12-23 US disclosed
EP-1489109-A2 Living and quasiliving cationic telechelic polymers quenched by N-substituted pyrrole and methods for their preparation Chevron Oronite Company LLC (US) 2004-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060063762-A1 Indole indazole and benzazole derivative ADRB3, ADRA2C, ADRB2 CDK2 2122/4885HSP90AA1 2822/4885IDO1 49/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.