Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | GSTP1 | P09211 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44767 | 0.90 | MAPK1 (0.40) | MAPTL3MBTL1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL44748 | 0.88 | NOTUM (0.38) | MAPTL3MBTL1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL43634 | 0.87 | MAPK1 (0.38) | MAPTL3MBTL1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL44261 | 0.86 | MAPT (0.35) | MAPTL3MBTL1POLBSMN1; SMN2LMNA | |
| SCHEMBL44205 | 0.85 | SMPD1 (0.35) | HPGDP2RX3SMPD1 | |
| SCHEMBL43903 | 0.85 | KMT2A (0.39) | FFAR1SIRT2GSTP1MAPTPOLB | |
| SCHEMBL44454 | 0.84 | CHEK2 (0.36) | MAPTPOLBLMNAP2RX3HTT | |
| SCHEMBL43952 | 0.84 | SMPD1 (0.36) | MAPTPOLBLMNASMPD1 | |
| SCHEMBL38269 | 0.83 | L3MBTL1 (0.39) | MAPTL3MBTL1HPGDSMN1; SMN2LMNA | |
| SCHEMBL16592880 | 0.83 | BRD4 (0.35) | FFAR1MAPTSMN1; SMN2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |