Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44205 | 0.91 | SMPD1 (0.35) | SMPD1PIK3CAS1PR1 | |
| SCHEMBL44632 | 0.91 | LMNA (0.36) | SMPD1LMNATP53MAPTTHRB | |
| SCHEMBL44454 | 0.90 | CHEK2 (0.36) | SMPD1GAALMNATP53MAPT | |
| SCHEMBL44541 | 0.89 | PDE4B (0.41) | TP53MAPTS1PR1 | |
| SCHEMBL44296 | 0.88 | MARK3 (0.39) | LMNAMAPTPOLB | |
| SCHEMBL44473 | 0.88 | GRM5 (0.40) | SMPD1LMNATP53MAPTTHRB | |
| SCHEMBL44225 | 0.86 | MAPT (0.50) | GAALMNATP53MAPTPOLB | |
| SCHEMBL43923 | 0.86 | POLQ (0.37) | PIK3CA | |
| SCHEMBL38269 | 0.85 | L3MBTL1 (0.39) | LMNAMAPTS1PR1 | |
| SCHEMBL16592880 | 0.85 | BRD4 (0.35) | TP53MAPTPIK3CAS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |