Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471817 | 1.00 | KDM4E (0.57) | KDM4EPOLBTDP1L3MBTL1PKM | |
| SCHEMBL25190825 | 0.83 | MAPT (0.54) | KDM4EPOLBTDP1PKMMEN1 | |
| SCHEMBL2690711 | 0.81 | HDAC1 (0.78) | PKMMEN1ALDH1A1KMT2AHDAC1 | |
| SCHEMBL2690712 | 0.81 | HDAC1 (0.78) | PKMMEN1ALDH1A1KMT2AHDAC1 | |
| SCHEMBL11110980 | 0.81 | POLB (0.56) | KDM4EPOLBTDP1L3MBTL1MEN1 | |
| SCHEMBL633994 | 0.79 | ALDH1A1 (0.68) | TDP1L3MBTL1PKMMEN1ALDH1A1 | |
| SCHEMBL1403082 | 0.79 | HDAC1 (0.78) | PKMMEN1ALDH1A1KMT2AHDAC1 | |
| SCHEMBL11131607 | 0.79 | ALDH1A1 (0.52) | TDP1L3MBTL1PKMMEN1ALDH1A1 | |
| SCHEMBL1403084 | 0.79 | HDAC1 (0.78) | PKMMEN1ALDH1A1KMT2AHDAC1 | |
| SCHEMBL3718775 | 0.79 | TSHR (0.65) | POLBTDP1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2093292-A2 | Inhibition of specific histone deacetylase isoforms | Methylgene, Inc. (CA) | 2009-08-26 | — | — | EP | disclosed |
| US-20040266718-A1 | Inhibition of specific histone deacetylase isoforms | LI ZUOMEI (CA) | 2004-12-30 | — | — | US | disclosed |
| EP-1438404-A2 | INHIBITION OF SPECIFIC HISTONE DEACETYLASE ISOFORMS | Methylgene, Inc. (CA) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003006652-A2 | INHIBITION OF SPECIFIC HISTONE DEACETYLASE ISOFORMS | METHYLGENE, INC. (CA) | 2003-01-23 | — | — | WO | disclosed |
| US-20020061860-A1 | Antisense oligonucleotide inhibition of specific histone deacetylase isoforms | METHYLGENE, INC. (CA) | 2002-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020061860-A1 | Antisense oligonucleotide inhibition of specific histone deacetylase isoforms | HDAC5, HDAC1, HDAC8 | KDM4E 737/4885POLB 166/4885TDP1 451/4885 |
| US-20040266718-A1 | Inhibition of specific histone deacetylase isoforms | HDAC1, HDAC5, HDAC3 | KDM4E 223/4885POLB 517/4885TDP1 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.