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Dronabinol

Dronabinol

SCHEMBL447183

CCCCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21.CN[C@@H](C)[C@H](O)c1ccccc1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CNR1

The experimentally established mechanism targets of Dronabinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CNR1 known ✓ P21554 9/20 0.72
▸ CNR2 P34972 16/20 0.72
▸ ABHD12 Q8N2K0 3/20 0.72
▸ ABHD6 Q9BV23 3/20 0.72
▸ FAAH O00519 2/20 0.72
▸ TRPM8 Q7Z2W7 2/20 0.72
▸ GPR55 Q9Y2T6 2/20 0.72
▸ NR1I2 O75469 1/20 0.72
▸ LDHA P00338 1/20 0.72
▸ GLRA1 P23415 1/20 0.72
▸ GPR183 P32249 1/20 0.72
▸ DRD3 P35462 1/20 0.72
▸ ENPP2 Q13822 1/20 0.72
▸ GPR18 Q14330 1/20 0.72
▸ KDR P35968 1/20 0.64
▸ TRPA1 O75762 1/20 0.63
▸ HTR1A P08908 1/20 0.63
▸ TRPV1 Q8NER1 1/20 0.63
▸ TRPV3 Q8NET8 1/20 0.63
▸ TRPV6 Q9H1D0 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dronabinol SCHEMBL30018684 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL3686519 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL13394311 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL1227386 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL13214137 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL24702729 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL11375978 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL4609 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL22705549 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH
Dronabinol SCHEMBL29349828 0.85 CNR2 (1.00) CNR2CNR1ABHD12ABHD6FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11433136-B2 Polyacetal polymers, conjugates, particles and uses thereof THE GENERAL HOSPITAL CORPORATION (US) 2022-09-06 — — US disclosed
US-20210085508-A1 NASAL CONGESTION, OBSTRUCTION RELIEF, AND DRUG DELIVERY SANOSTEC CORP (US) 2021-03-25 — — US disclosed
EP-2019691-B1 POLYMERS FOR FUNCTIONAL PARTICLES MASSACHUSETTS INST TECHNOLOGY (US) 2020-08-12 — — EP disclosed
US-10639186-B2 Nasal congestion, obstruction relief, and drug delivery SANOSTEC CORP. (US) 2020-05-05 — — US disclosed
EP-2259803-B2 DEVICE FOR PROMOTION OF HEMOSTASIS AND/OR WOUND HEALING FERROSAN MEDICAL DEVICES AS (DK) 2019-03-13 — — EP disclosed
US-20180360978-A1 POLYACETAL POLYMERS, CONJUGATES, PARTICLES AND USES THEREOF THE GENERAL HOSPITAL CORPORATION (US) 2018-12-20 — — US disclosed
EP-3389720-A1 POLYACETAL POLYMERS, CONJUGATES, PARTICLES AND USES THEREOF The General Hospital Corporation (US) 2018-10-24 — — EP disclosed
US-9993439-B2 Mucoadhesive nanoparticle delivery system UNIVERSITY OF WATERLOO (CA) 2018-06-12 — — US disclosed
EP-2863892-B1 MUCOADHESIVE NANOPARTICLE DELIVERY SYSTEM UNIV WATERLOO (CA) 2017-11-08 — — EP disclosed
WO-2017165583-A1 NASAL INSERT HAVING ONE OR MORE SENSORS SANOSTEC CORP (US) 2017-09-28 — — WO disclosed
WO-2000047236-A1 MATRICES FOR DRUG DELIVERY AND METHODS FOR MAKING AND USING THE SAME BIOSTREAM, INC. (US) 2000-08-17 — — WO disclosed
EP-0705085-B1 MOLECULAR TRANSDERMAL TRANSPORT SYSTEM MASIZ JOHN J (US) 2000-03-22 — — EP disclosed
US-5853751-A Molecular transdermal transport system BIO STRATEGIES, LP 1998-12-29 — — US disclosed
WO-1998046286-A1 BIODEGRADABLE COMPOUNDS, COMPOSITIONS, ARTICLES AND METHODS FOR MAKING AND USING THE SAME JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) 1998-10-22 — — WO disclosed
US-5645854-A Molecular transdermal transport system BIO STRATEGIES, LP 1997-07-08 — — US disclosed
EP-0705085-A4 MOLECULAR TRANSDERMAL TRANSPORT SYSTEM MASIZ JOHN J (US) 1997-06-04 — — EP disclosed
WO-1997013482-A1 MOLECULAR TRANSDERMAL TRANSPORT SYSTEM MASIZ JOHN J (US) 1997-04-17 — — WO disclosed
EP-0705085-A1 MOLECULAR TRANSDERMAL TRANSPORT SYSTEM Masiz, John J. (US) 1996-04-10 — — EP disclosed
US-5460821-A Molecular transdermal transport system BIO STRATEGIES, LP 1995-10-24 — — US disclosed
WO-1995000088-A1 MOLECULAR TRANSDERMAL TRANSPORT SYSTEM MASIZ JOHN J (US) 1995-01-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180360978-A1 POLYACETAL POLYMERS, CONJUGATES, PARTICLES AND USES THEREOF CD44, FUT6, MSN CNR1 4716/4885CNR2 4755/4885ABHD12 1315/4885
US-11433136-B2 Polyacetal polymers, conjugates, particles and uses thereof CD44, FUT6, MSN CNR1 4716/4885CNR2 4755/4885ABHD12 1315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.