Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.59 |
| ▸ | F7 | P08709 | 1/20 | 0.59 |
| ▸ | F3 | P13726 | 1/20 | 0.59 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.59 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.59 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.59 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacinamide SCHEMBL28309509 | 1.00 | SIRT2 (0.59) | SIRT2F7F3SARM1SIRT6 | |
| Adonitol SCHEMBL27591282 | 0.84 | F7 (0.69) | SIRT2F7F3SARM1SIRT6 | |
| Mannitol SCHEMBL9807801 | 0.84 | F7 (0.69) | SIRT2F7F3SARM1SIRT6 | |
| Xylose SCHEMBL938610 | 0.83 | F7 (0.58) | SIRT2F7F3SARM1SIRT6 | |
| Xylose SCHEMBL23925306 | 0.83 | F7 (0.58) | SIRT2F7F3SARM1SIRT6 | |
| Xylose SCHEMBL28724079 | 0.82 | F7 (0.56) | SIRT2F7F3SARM1SIRT6 | |
| Demannose SCHEMBL27666893 | 0.82 | F7 (0.56) | SIRT2F7F3SARM1SIRT6 | |
| Xylose SCHEMBL20423632 | 0.82 | F7 (0.56) | SIRT2F7F3SARM1SIRT6 | |
| Niacinamide SCHEMBL27877775 | 0.81 | F7 (0.73) | SIRT2F7F3SARM1SIRT6 | |
| Niacinamide SCHEMBL810723 | 0.80 | F7 (0.58) | SIRT2F7F3SARM1SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504489-B2 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2009-03-17 | — | — | US | disclosed |
| US-7056894-B2 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-06-06 | — | — | US | disclosed |
| US-20060084616-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2006-04-20 | — | — | US | disclosed |
| EP-1370139-A2 | INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES, AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2003-12-17 | — | — | EP | disclosed |
| US-20020132783-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2002-09-19 | — | — | US | disclosed |
| WO-2002059084-A2 | INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES, AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020132783-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | CD38, ADPRS, NTPCR | SIRT2 731/4885F7 4070/4885F3 1181/4885 |
| US-20060084616-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof | CD38, ADPRS, NTPCR | SIRT2 692/4885F7 4201/4885F3 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.