Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 3/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068055 | 0.90 | RIPK1 (0.55) | RIPK1BTKTBK1CDK1HDAC3 | |
| SCHEMBL4463465 | 0.88 | RIPK1 (0.53) | RIPK1BTKTBK1CDK1HDAC3 | |
| SCHEMBL4065929 | 0.85 | RIPK1 (0.60) | RIPK1BTKTBK1HDAC3ERBB2 | |
| SCHEMBL4467559 | 0.82 | CSF1R (0.55) | HDAC3ERBB2KDRHDAC4HDAC1 | |
| SCHEMBL4473017 | 0.82 | RIPK1 (0.57) | RIPK1BTKTBK1ALKEGFR | |
| SCHEMBL4068131 | 0.82 | RIPK1 (0.57) | RIPK1BTKTBK1HDAC3ERBB2 | |
| SCHEMBL4063817 | 0.82 | RIPK1 (0.59) | RIPK1BTKTBK1ALKEGFR | |
| SCHEMBL13604152 | 0.81 | RIPK1 (0.53) | RIPK1BTKTBK1ALKEGFR | |
| SCHEMBL4068059 | 0.80 | RIPK1 (0.55) | RIPK1BTKTBK1ALKEGFR | |
| SCHEMBL4467935 | 0.80 | RIPK1 (0.64) | RIPK1BTKTBK1ALKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135460-A1 | 7H-pyrrolopyrimidine derivatives | CARAVATTI GIORGIO | 2007-06-14 | — | — | US | claimed |
| EP-1718651-A2 | 7H-PYRROLOPYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2006-11-08 | — | — | EP | claimed |
| WO-2005077951-A2 | 7H-PYRROLOPYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2005-08-25 | — | — | WO | claimed |
| US-7625894-B2 | Pyrrolo[2,3-d]Pyrimidines as Protein Tyrosine Kinase Inhibitors | NOVARTIS AG (CH) | 2009-12-01 | — | — | US | disclosed |
| US-20070135460-A1 | 7H-pyrrolopyrimidine derivatives | CARAVATTI GIORGIO | 2007-06-14 | — | — | US | disclosed |
| EP-1718651-A2 | 7H-PYRROLOPYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077951-A2 | 7H-PYRROLOPYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135460-A1 | 7H-pyrrolopyrimidine derivatives | DPYD, TYMP, DHPS | RIPK1 3871/4885BTK 2976/4885TBK1 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.