Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27009178 | 0.84 | NPC1 (0.51) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL4714412 | 0.83 | SMN1; SMN2 (0.54) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL4475058 | 0.83 | MEN1 (0.46) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL4494427 | 0.83 | SMN1; SMN2 (0.44) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL3661525 | 0.82 | SMN1; SMN2 (0.58) | RAB9ANPC1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL23402126 | 0.81 | RIPK2 (0.48) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL13974490 | 0.80 | RAB9A (0.65) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL29767107 | 0.80 | RAB9A (0.65) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL27009185 | 0.77 | RIPK2 (0.44) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL27009180 | 0.76 | NPC1 (0.41) | RAB9ANPC1ALDH1A1SMN1; SMN2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485658-B2 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| EP-1664032-B1 | N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL C-KIT INHIBITORS | OSI PHARM INC (US) | 2008-11-05 | — | — | EP | disclosed |
| US-20080221187-A9 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | OSI PHARMACEUTICALS, INC. | 2008-09-11 | — | — | US | disclosed |
| EP-1664032-A1 | N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL C-KIT INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20060035951-A1 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | BOLGER JOSHUA | 2006-02-16 | — | — | US | disclosed |
| WO-2005021537-A1 | N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL C-KIT INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221187-A9 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | KIT, TNNI3K, CHUK | RAB9A 977/4885NPC1 2213/4885ALDH1A1 655/4885 |
| US-20060035951-A1 | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors | KIT, TNNI3K, CHUK | RAB9A 977/4885NPC1 2213/4885ALDH1A1 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.