Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4461708 | 0.94 | HTR6 (0.38) | HTR6SIGMAR1KDM4EHTR2ALMNA | |
| Hydrochloric Acid SCHEMBL4462018 | 0.93 | HTR6 (0.38) | HTR6SIGMAR1KDM4EHTR2ALMNA | |
| Hydrochloric Acid SCHEMBL4463069 | 0.85 | HTR6 (0.32) | HTR6 | |
| Hydrochloric Acid SCHEMBL4459355 | 0.84 | HTR6 (0.43) | HTR6SIGMAR1KDM4EHTR2ALMNA | |
| Hydrochloric Acid SCHEMBL4472715 | 0.83 | HTR6 (0.40) | HTR6SIGMAR1KDM4EHTR2ALMNA | |
| Hydrochloric Acid SCHEMBL4463820 | 0.83 | HTR6 (0.30) | HTR6 | |
| Hydrochloric Acid SCHEMBL4479874 | 0.81 | HTR6 (0.40) | HTR6SIGMAR1KDM4EHTR2ALMNA | |
| SCHEMBL4463037 | 0.80 | HTR6 (0.42) | HTR6SIGMAR1KDM4EHTR2ALMNA | |
| Hydrochloric Acid SCHEMBL4476406 | 0.80 | KDM4E (0.30) | HTR6KDM4EHTR2ALMNATP53 | |
| Hydrochloric Acid SCHEMBL4464830 | 0.79 | HTR6 (0.39) | HTR6SIGMAR1KDM4EHTR2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1671983-B1 | Catalysts compositions for the polymerization and copolymerization of alpha-olefins | REPSOL QUIMICA SA (ES) | 2009-02-25 | — | — | EP | claimed |