Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.55 |
| ▸ | MMP12 | P39900 | 10/20 | 0.55 |
| ▸ | MMP13 | P45452 | 10/20 | 0.55 |
| ▸ | MMP14 | P50281 | 10/20 | 0.55 |
| ▸ | MMP8 | P22894 | 9/20 | 0.55 |
| ▸ | MMP16 | P51512 | 9/20 | 0.55 |
| ▸ | MMP9 | P14780 | 9/20 | 0.55 |
| ▸ | MMP1 | P03956 | 7/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 7/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9228365 | 0.81 | PTGS2 (0.61) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL1344982 | 0.80 | MCL1 (0.46) | PTGS2AKR1C3PTGS1LMNACYP2C9 | |
| SCHEMBL1345631 | 0.80 | PTGS2 (0.45) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL1345419 | 0.80 | PTGS2 (0.45) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL1343601 | 0.80 | MCL1 (0.46) | PTGS2AKR1C3PTGS1LMNACYP2C9 | |
| SCHEMBL10181290 | 0.79 | HSD11B1 (0.59) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL7266402 | 0.77 | HSD11B1 (0.61) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL166813 | 0.75 | PTGS2 (0.53) | PTGS2AKR1C3AKR1C2PTGS1LMNA | |
| SCHEMBL27733563 | 0.75 | HSD11B1 (0.55) | MMP2MMP12MMP13MMP14MMP8 | |
| SCHEMBL13210403 | 0.75 | HSD11B1 (0.59) | MMP2MMP12MMP13MMP14MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455773-B1 | 2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-11-04 | — | — | EP | disclosed |