⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175178 | 0.94 | CYP1A2 (0.42) | — | |
| SCHEMBL31287865 | 0.92 | KCNH2 (0.42) | — | |
| SCHEMBL11892701 | 0.86 | — | — | |
| SCHEMBL2089074 | 0.78 | CYP1A2 (0.37) | — | |
| SCHEMBL2089072 | 0.74 | CYP1A2 (0.33) | — | |
| SCHEMBL16068283 | 0.73 | — | — | |
| SCHEMBL358647 | 0.73 | — | — | |
| SCHEMBL11513503 | 0.73 | — | — | |
| SCHEMBL21186379 | 0.70 | PRSS1 (0.38) | — | |
| SCHEMBL4312689 | 0.69 | ALOX5 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3453707-B1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2022-02-16 | — | — | EP | disclosed |
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |
| EP-3453707-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2019-03-13 | — | — | EP | disclosed |
| EP-1934238-B1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2017-06-28 | — | — | EP | disclosed |
| CN-102639539-A | Process for the preparation of imidazo [2,1-b ] [1,3] benzothiazole derivatives | AMBIT BIOSCIENCES CORP | 2012-08-15 | — | — | CN | disclosed |
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1856079-A4 | SPIRO-HETEROCYCLIC CHROMANS, THIOCHROMANS AND DIHYDROQUINOLINES | GALILEO PHARMACEUTICALS INC (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20080207588-A1 | Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines | CHU DANIEL T W | 2008-08-28 | — | — | US | disclosed |
| CN-101163687-A | Spiro-heterocyclic chromans, thiochromans and dihydroquinolines | GALILEO PHARMACEUTICALS INC (US) | 2008-04-16 | — | — | CN | disclosed |
| EP-1856079-A1 | SPIRO-HETEROCYCLIC CHROMANS, THIOCHROMANS AND DIHYDROQUINOLINES | Galileo Pharmaceuticals, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1856040-A2 | NOVEL LIPOXYGENASE INHIBITORS | Eli Lilly and Company (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1836183-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | Galileo Pharmaceuticals, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006093548-A1 | SPIRO-HETEROCYCLIC CHROMANS, THIOCHROMANS AND DIHYDROQUINOLINES | GALILEO PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |
| WO-2006093547-A2 | NOVEL LIPOXYGENASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060193797-A1 | Chroman derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC | 2006-08-31 | — | — | US | disclosed |
| WO-2006065686-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | GALILEO PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |
| US-20060128790-A1 | Spiro derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC. | 2006-06-15 | — | — | US | disclosed |
| CN-1213658-C | Pyridinecarboxamide derivative and pest control agent containing same as active ingredient | MEIJI SEIKA KAISHA (JP) | 2005-08-10 | — | — | CN | disclosed |
| CN-1329596-A | Pyridinecarboxamide derivative and pest control agent containing same as active ingredient | MEIJI SEIKA KAISHA (JP) | 2002-01-02 | — | — | CN | disclosed |