Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.55 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21640577 | 0.98 | ALDH1A1 (0.58) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL9906308 | 0.88 | ALDH1A1 (0.57) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL2994259 | 0.88 | ALDH1A1 (0.57) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL5123195 | 0.87 | TDP1 (0.69) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL18977797 | 0.87 | TDP1 (0.62) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL5124500 | 0.84 | TDP1 (0.66) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL5119694 | 0.84 | TDP1 (0.66) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL5190400 | 0.83 | KMT2A (0.54) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL5418744 | 0.83 | TDP1 (0.64) | ALDH1A1TDP1L3MBTL1RECQLKMT2A | |
| SCHEMBL5129675 | 0.83 | TDP1 (0.64) | ALDH1A1TDP1L3MBTL1RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |