Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chromanone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.55 |
| ▸ | MAOB | P27338 | 6/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chromanone SCHEMBL4459476 | 0.93 | GRM5 (0.52) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL28794 | 0.92 | MAOB (0.56) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL28205525 | 0.92 | MAOB (0.56) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL29384996 | 0.92 | MAOB (0.56) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL4463263 | 0.91 | MAOB (0.53) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL28463260 | 0.90 | MAOB (0.55) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL29349977 | 0.90 | MAOB (0.55) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL28719460 | 0.90 | MAOB (0.55) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL30017864 | 0.90 | MAOB (0.55) | GRM5MAOBMAOANPC1RAB9A | |
| Chromanone SCHEMBL27846233 | 0.90 | MAOB (0.55) | GRM5MAOBMAOANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004103985-A2 | DERIVATIVES OF FUSAROCHROMANONE AS THERAPEUTIC AGENTS | UNIVERSITY OF SOUTH CAROLINA (US) | 2004-12-02 | — | — | WO | claimed |
| US-7598403-B2 | Synthesis of chromanones | THE UNIVERSITY OF SOUTH CAROLINA RESEARCH FOUNDATION (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070203214-A1 | Synthesis Of Chromanones | UNIVERSITY OF SOUTH CAROLINA (US) | 2007-08-30 | — | — | US | disclosed |
| WO-2004103985-A2 | DERIVATIVES OF FUSAROCHROMANONE AS THERAPEUTIC AGENTS | UNIVERSITY OF SOUTH CAROLINA (US) | 2004-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203214-A1 | Synthesis Of Chromanones | MAP3K6, MAP3K8, MAP3K1 | GRM5 3423/4885MAOB 1582/4885MAOA 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.