Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20077252 | 0.85 | ALDH1A1 (0.50) | ALDH1A1CYP3A4MAPTTP53HSP90AA1 | |
| SCHEMBL3555893 | 0.85 | CYP3A4 (0.49) | ALDH1A1CYP3A4MAPTTP53HSP90AA1 | |
| SCHEMBL6561725 | 0.82 | ALDH1A1 (0.44) | ALDH1A1CYP3A4MAPTHSP90AA1HPGD | |
| SCHEMBL4518802 | 0.81 | ALDH1A1 (0.41) | ALDH1A1CYP3A4HSP90AA1HPGDHTT | |
| SCHEMBL14117285 | 0.81 | TRPA1 (0.52) | ALDH1A1CYP3A4HSP90AA1HPGDPDK2 | |
| SCHEMBL8875590 | 0.80 | MAPT (0.43) | ALDH1A1CYP3A4MAPTNPC1RAB9A | |
| SCHEMBL11984397 | 0.80 | SMN1; SMN2 (0.57) | ALDH1A1MAPTTP53HPGDNPC1 | |
| SCHEMBL18075547 | 0.80 | SMN1; SMN2 (0.43) | ALDH1A1CYP3A4MAPTNPC1RAB9A | |
| SCHEMBL5208590 | 0.80 | ALDH1A1 (0.42) | ALDH1A1CYP3A4MAPTHSP90AA1HPGD | |
| SCHEMBL4508222 | 0.79 | TRPA1 (0.37) | ALDH1A1CYP3A4MAPTTP53HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | ALDH1A1 780/4885CYP3A4 639/4885MAPT 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.