Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 2/20 | 0.54 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.46 |
| ▸ | HTR3B | O95264 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11878505 | 0.80 | PLAU (0.54) | KMT2APLAUHGFACADRA2AADRA2B | |
| SCHEMBL11880304 | 0.80 | PLAU (0.54) | KMT2APLAUHGFACADRA2AADRA2B | |
| SCHEMBL11876448 | 0.80 | GRIN2D (0.66) | KMT2APLAUADRA2AADRA2BADRA2C | |
| SCHEMBL10788312 | 0.79 | HSD17B10 (0.62) | KMT2AHSD17B10MEN1NPC1ALDH1A1 | |
| SCHEMBL1513945 | 0.78 | HSD17B10 (0.56) | KMT2AHSD17B10MEN1NPC1ALDH1A1 | |
| SCHEMBL29471399 | 0.78 | HSD17B10 (0.56) | KMT2AHSD17B10MEN1NPC1ALDH1A1 | |
| Nitric Acid SCHEMBL3858362 | 0.78 | GRIN2D (0.63) | KMT2APLAUADRA2AADRA2BADRA2C | |
| SCHEMBL11878490 | 0.78 | PLAU (0.51) | KMT2APLAUADRA2AADRA2BADRA2C | |
| SCHEMBL11879323 | 0.77 | ALDH1A1 (0.55) | KMT2AHSD17B10PLAUHGFACADRA2A | |
| SCHEMBL9638395 | 0.77 | HSD17B10 (0.60) | KMT2AHSD17B10MEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501415-B2 | Selective inhibitors of ERK protein kinase and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1833820-A1 | SELECTIVE INHIBITORS OF ERK PROTEIN KINASE AND USES THEROF | Vertex Pharmaceuticals Incorporated (US) | 2007-09-19 | — | — | EP | disclosed |
| US-20060160807-A1 | Selective inhibitors of ERK protein kinase and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2006-07-20 | — | — | US | disclosed |
| WO-2006071644-A1 | SELECTIVE INHIBITORS OF ERK PROTEIN KINASES AND USES THEROF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-07-06 | — | — | WO | disclosed |
| US-3976643-A | FROM AN ANILINE AND CYANAMIDE | WILLIAM H. RORER, INC. (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160807-A1 | Selective inhibitors of ERK protein kinase and uses thereof | MAP3K20, MAP4K2, MAP4K1 | KMT2A 3000/4885HSD17B10 2581/4885PLAU 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.