Sugi Predict

Sugi Predict / Compounds / SCHEMBL4477277

SCHEMBL4477277

SCHEMBL4477277

COC(=O)c1sccc1NC(=O)c1c(F)cccc1F

nearest known ligand 0.76

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.71
▸ MEN1 O00255 3/20 0.71
▸ POLB P06746 2/20 0.71
▸ MAPT P10636 3/20 0.67
▸ L3MBTL1 Q9Y468 1/20 0.64
▸ KDM4E B2RXH2 4/20 0.63
▸ NPSR1 Q6W5P4 2/20 0.63
▸ HPGD P15428 5/20 0.62
▸ SMN1; SMN2 Q16637 2/20 0.62
▸ MAPK10 P53779 2/20 0.59
▸ ALDH1A1 P00352 2/20 0.59
▸ LMNA P02545 1/20 0.59
▸ HSD17B10 Q99714 3/20 0.59
▸ MAPK1 P28482 2/20 0.59
▸ PKM P14618 2/20 0.58
▸ USP2 O75604 1/20 0.58
▸ ALOX15 P16050 1/20 0.58
▸ GAA P10253 2/20 0.57
▸ NPC1 O15118 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13789426 0.83 MEN1 (0.52) KMT2AMEN1POLBMAPTL3MBTL1
SCHEMBL13789344 0.80 ALDH1A1 (0.62) KMT2APOLBMAPTL3MBTL1KDM4E
SCHEMBL14103873 0.78 ALDH1A1 (0.70) KMT2AMEN1POLBMAPTL3MBTL1
SCHEMBL14104058 0.78 KMT2A (0.70) KMT2APOLBMAPTL3MBTL1KDM4E
SCHEMBL9070025 0.78 L3MBTL1 (1.00) KMT2AMEN1POLBMAPTL3MBTL1
SCHEMBL259605 0.76 MAPT (1.00) KMT2AMEN1POLBMAPTL3MBTL1
SCHEMBL14104057 0.76 MAPT (0.77) KMT2AMEN1POLBMAPTL3MBTL1
SCHEMBL29397956 0.76 MAPT (1.00) KMT2AMEN1POLBMAPTL3MBTL1
SCHEMBL7395977 0.76 CYP1A2 (0.55) KMT2AMEN1POLBMAPTKDM4E
SCHEMBL1367369 0.76 NPC1 (0.71) KMT2AMEN1POLBMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A KMT2A 2234/4885MEN1 2737/4885POLB 248/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A KMT2A 2234/4885MEN1 2737/4885POLB 248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.