Sugi Predict

Sugi Predict / Compounds / SCHEMBL4477907

SCHEMBL4477907

SCHEMBL4477907

N#Cc1c(Nc2ccc(Cl)cc2)sc(C(=O)c2ccc(Cl)cc2Cl)c1N

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.59
▸ ALDH1A1 P00352 5/20 0.57
▸ KMT2A Q03164 3/20 0.57
▸ HPGD P15428 2/20 0.57
▸ MEN1 O00255 2/20 0.57
▸ ALOX12 P18054 1/20 0.57
▸ GAA P10253 1/20 0.57
▸ MAPK1 P28482 2/20 0.54
▸ HTT P42858 1/20 0.54
▸ POLB P06746 3/20 0.52
▸ LMNA P02545 3/20 0.52
▸ CYP1A2 P05177 1/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ CYP2D6 P10635 1/20 0.50
▸ CYP2C9 P11712 1/20 0.50
▸ CYP2C19 P33261 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ MELK Q14680 5/20 0.45
▸ KDM4E B2RXH2 1/20 0.44
▸ RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13633822 0.85 ALDH1A1 (0.78) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL4477464 0.82 ALDH1A1 (0.57) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL2132850 0.81 ALDH1A1 (0.71) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL632590 0.80 MAPT (0.80) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL633259 0.80 ALDH1A1 (0.89) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL4465841 0.80 MAPT (0.84) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL4476614 0.79 MAPT (0.58) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL632367 0.78 ALDH1A1 (0.67) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL2133817 0.78 ALDH1A1 (0.67) MAPTALDH1A1KMT2AHPGDMEN1
SCHEMBL632059 0.78 ALDH1A1 (0.67) MAPTALDH1A1KMT2AHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A MAPT 3524/4885ALDH1A1 802/4885KMT2A 2234/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A MAPT 3524/4885ALDH1A1 802/4885KMT2A 2234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.