Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.89 |
| ▸ | HPGD | P15428 | 3/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.89 |
| ▸ | MEN1 | O00255 | 2/20 | 0.89 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.89 |
| ▸ | MAPT | P10636 | 9/20 | 0.80 |
| ▸ | LMNA | P02545 | 6/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.80 |
| ▸ | HTT | P42858 | 2/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | MELK | Q14680 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633822 | 0.94 | ALDH1A1 (0.78) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL2132850 | 0.90 | ALDH1A1 (0.71) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL632590 | 0.89 | MAPT (0.80) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL4465841 | 0.89 | MAPT (0.84) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL2131953 | 0.88 | ALDH1A1 (0.69) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL632059 | 0.87 | ALDH1A1 (0.67) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL632367 | 0.87 | ALDH1A1 (0.67) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL2133817 | 0.87 | ALDH1A1 (0.67) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL4481501 | 0.87 | ALDH1A1 (0.67) | ALDH1A1HPGDKMT2AMEN1ALOX12 | |
| SCHEMBL4473082 | 0.87 | ALDH1A1 (0.85) | ALDH1A1HPGDKMT2AMEN1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410163-B2 | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | TELIK, INC. (US) | 2013-04-02 | — | — | US | claimed |
| US-20120101286-A1 | SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBONITRILES AND SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBOXAMIDES AS TUBULIN POLYMERIZATION INHIBITORS | TELIK INC. (US) | 2012-04-26 | — | — | US | claimed |
| EP-2419424-A2 | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | Telik, Inc. (US) | 2012-02-22 | — | — | EP | claimed |
| WO-2010120400-A2 | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | TELIK, INC. (US) | 2010-10-21 | — | — | WO | claimed |
| US-8410163-B2 | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | TELIK, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| US-20120101286-A1 | SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBONITRILES AND SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBOXAMIDES AS TUBULIN POLYMERIZATION INHIBITORS | TELIK INC. (US) | 2012-04-26 | — | — | US | disclosed |
| WO-2010120400-A2 | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | TELIK, INC. (US) | 2010-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101286-A1 | SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBONITRILES AND SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBOXAMIDES AS TUBULIN POLYMERIZATION INHIBITORS | TUBB3, TUBB4A, TUBB | ALDH1A1 2184/4885HPGD 4295/4885KMT2A 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.