SCHEMBL4478

SCHEMBL4478

Cc1noc(-c2ccc(Br)cc2)c1C#CCO

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.41
HDAC6 Q9UBN7 3/20 0.41
HDAC3 O15379 2/20 0.41
HDAC2 Q92769 2/20 0.41
NCOR2 Q9Y618 2/20 0.41
TP53 P04637 3/20 0.36
HTT P42858 2/20 0.36
MAPT P10636 2/20 0.36
RECQL P46063 1/20 0.36
NR2F2 P24468 1/20 0.36
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CTDSP1 Q9GZU7 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
SMPD1 P17405 1/20 0.33
HDAC8 Q9BY41 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1680143 0.82 MEN1 (0.35) HDAC1HDAC6HDAC3HDAC2NCOR2
SCHEMBL11386 0.79 HDAC3 (0.39) HDAC1HDAC6HDAC3HDAC2NCOR2
SCHEMBL1683 0.74 CYP1A2 (0.43) TP53HTTMAPTCYP1A2CYP3A4
SCHEMBL1652 0.72 CYP1A2 (0.41) HDAC1TP53MAPTCYP1A2CYP3A4
SCHEMBL27886960 0.71 EDNRB (0.45) TP53HTTMAPTCYP1A2CYP3A4
SCHEMBL1279 0.70 CYP1A2 (0.43) TP53HTTMAPTCYP1A2CYP3A4
SCHEMBL4477 0.70 MEN1 (0.33) TP53HTTMAPTCYP1A2CYP3A4
SCHEMBL1606639 0.70 CYP1A2 (0.40) TP53HTTMAPTCYP1A2CYP3A4
SCHEMBL14785 0.70 MEN1 (0.33) TP53HTTMAPTCYP1A2CYP3A4
SCHEMBL1185 0.69 CYP1A2 (0.44) TP53HTTMAPTCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483269-A2 POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483251-A2 POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041461-A2 POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041462-A2 POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed