SCHEMBL11386

SCHEMBL11386

Cc1noc(-c2ccc(Br)cc2)c1C#CCNS(C)(=O)=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.39
HDAC1 Q13547 2/20 0.39
HDAC2 Q92769 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
NCOR2 Q9Y618 2/20 0.39
EDNRB P24530 9/20 0.37
EDNRA P25101 9/20 0.37
TDP1 Q9NUW8 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
TSHR P16473 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
PTGS2 P35354 2/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4478 0.79 HDAC1 (0.41) HDAC3HDAC1HDAC2HDAC6NCOR2
SCHEMBL1680143 0.76 MEN1 (0.35) HDAC3HDAC1HDAC2HDAC6NCOR2
SCHEMBL4560 0.71 EDNRB (0.37) EDNRBEDNRATDP1CYP1A2CYP3A4
SCHEMBL4107 0.70 EDNRB (0.36) EDNRBEDNRATDP1CYP1A2CYP3A4
SCHEMBL7206 0.68 POLB (0.37) EDNRBEDNRATDP1CYP1A2CYP3A4
SCHEMBL6513072 0.66 PTGS2 (0.56) EDNRBEDNRATDP1CYP1A2CYP3A4
SCHEMBL1709 0.66 TDP1 (0.45) HDAC1EDNRBEDNRATDP1CYP1A2
SCHEMBL27886960 0.66 EDNRB (0.45) EDNRBEDNRATDP1CYP1A2CYP3A4
SCHEMBL1921 0.66 BRD4 (0.41) EDNRBEDNRATDP1CYP1A2CYP3A4
SCHEMBL6517910 0.65 CA2 (0.54) EDNRBEDNRATDP1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483251-A2 POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041462-A2 POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed