Cadaverine Tartrate — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CHRM1 CHRM2 CHRM3 CHRM4 ESR1 ESR2 GABRA1 GABRB1 GABRG2 GBA1 HRH1 HTR1D HTR2A OPRD1 OPRK1 OPRM1 SLC6A2 SLC6A3 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	SLC6A2 known ✓	P23975	14/20	0.41

▸	SLC6A3 known ✓	Q01959	3/20	0.40

▸	SLC6A4	P31645	16/20	0.41

▸	CYP2D6	P10635	4/20	0.38

▸	CYP3A4	P08684	1/20	0.38

▸	CYP2C9	P11712	1/20	0.38

▸	CYP2C19	P33261	1/20	0.38

▸	KCNH2	Q12809	3/20	0.38

▸	CETP	P11597	1/20	0.37

▸	TACR1	P25103	2/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4493066	0.91	SLC6A4 (0.47)	SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4
Cadaverine Tartrate SCHEMBL4495055	0.83	SLC6A4 (0.50)	SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4
Cadaverine Tartrate SCHEMBL4492714	0.78	SLC6A4 (0.47)	SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4
Cadaverine Tartrate SCHEMBL4483577	0.77	SLC6A2 (0.69)	SLC6A4SLC6A2SLC6A3CYP2D6KCNH2
Acetic Acid SCHEMBL4480219	0.77	SLC6A4 (0.54)	SLC6A4SLC6A2SLC6A3CYP2D6KCNH2
Cadaverine Tartrate SCHEMBL4486560	0.76	SLC6A2 (0.47)	SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4
Cadaverine Tartrate SCHEMBL4500877	0.75	SLC6A4 (0.57)	SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4
SCHEMBL5821154	0.75	SLC6A4 (0.56)	SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4
SCHEMBL4485877	0.75	SLC6A4 (0.56)	SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4
Cadaverine Tartrate SCHEMBL4483171	0.73	SLC6A4 (0.64)	SLC6A4SLC6A2SLC6A3CYP2D6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7619096-B2	3-Aminopyrrolidines as inhibitors of monoamine uptake	ELI LILLY AND COMPANY (US)	2009-11-17	—	—	US	disclosed
EP-1638934-B1	3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE	LILLY CO ELI (US)	2008-01-09	—	—	EP	disclosed
US-20060270713-A1	3-Aminopyrrolidines as inhibitors of monoamine uptake	ELI LILLY AND COMPANY	2006-11-30	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20060270713-A1	3-Aminopyrrolidines as inhibitors of monoamine uptake	SLC6A2, SLC6A3, SLC18A2	SLC6A2 1/4885SLC6A3 2/4885SLC6A4 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.