Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479600 | 1.00 | PTGS2 (0.50) | PTGS2CYP1A2CYP2C19POLBTDP1 | |
| SCHEMBL4469208 | 0.88 | POLB (0.55) | PTGS2POLBTDP1MEN1KMT2A | |
| SCHEMBL4469219 | 0.88 | POLB (0.55) | PTGS2POLBTDP1MEN1KMT2A | |
| SCHEMBL4477520 | 0.88 | GAA (0.42) | PTGS2POLBTDP1PTGS1GSK3B | |
| SCHEMBL4477514 | 0.88 | GAA (0.42) | PTGS2POLBTDP1PTGS1GSK3B | |
| SCHEMBL4469574 | 0.83 | PTGS2 (0.51) | PTGS2CYP1A2CYP2C19POLBTDP1 | |
| SCHEMBL4469564 | 0.83 | PTGS2 (0.51) | PTGS2CYP1A2CYP2C19POLBTDP1 | |
| SCHEMBL4488848 | 0.80 | PTGS2 (0.55) | PTGS2PTGS1GSK3BALDH1A1 | |
| SCHEMBL4479731 | 0.80 | ALDH1A1 (0.50) | POLBTDP1GSK3BALDH1A1 | |
| SCHEMBL4479726 | 0.80 | ALDH1A1 (0.50) | POLBTDP1GSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582630-B2 | Pyradazine compounds as GSK-3 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-01 | — | — | US | disclosed |
| EP-1551842-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004035588-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |