Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | STK16 | O75716 | 1/20 | 0.47 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.47 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480187 | 0.88 | GSK3B (0.59) | GSK3BFGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL4485340 | 0.87 | AAK1 (0.62) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4495365 | 0.87 | HDAC1 (0.61) | GSK3BFGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL4488734 | 0.87 | GSK3B (0.53) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4494624 | 0.87 | GSK3B (0.53) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4490359 | 0.87 | MAPK1 (0.55) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4492570 | 0.86 | GSK3B (0.59) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4497732 | 0.86 | GSK3B (0.69) | GSK3BGSK3AHDAC1HDAC2HDAC8 | |
| SCHEMBL4498152 | 0.86 | GSK3B (0.52) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4502574 | 0.86 | GSK3B (0.57) | GSK3BFGFR1FGFR2FGFR3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |