Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476606 | 0.84 | MEN1 (0.51) | F2RL3SMN1; SMN2RECQLMAPK10POLB | |
| SCHEMBL4470865 | 0.84 | PTGER4 (0.64) | PTGER4 | |
| SCHEMBL363569 | 0.81 | F2RL3 (1.00) | F2RL3CYP19A1SMN1; SMN2RECQLMAPK10 | |
| SCHEMBL29403731 | 0.81 | F2RL3 (1.00) | F2RL3CYP19A1SMN1; SMN2RECQLMAPK10 | |
| SCHEMBL4494497 | 0.80 | ALDH1A1 (0.53) | CYP19A1SMN1; SMN2TDP1PTGER4ALDH1A1 | |
| SCHEMBL25966955 | 0.80 | PTGER4 (0.64) | F2RL3CYP19A1SMN1; SMN2RECQLMAPK10 | |
| SCHEMBL4487658 | 0.80 | HDAC6 (0.56) | PTGER4 | |
| SCHEMBL4481481 | 0.80 | PTGER4 (0.55) | MAPTPTGER4MEN1KMT2AGAA | |
| SCHEMBL17322917 | 0.79 | PTGER4 (0.60) | F2RL3CYP19A1SMN1; SMN2RECQLMAPK10 | |
| SCHEMBL27669290 | 0.76 | L3MBTL1 (0.56) | SMN1; SMN2MAPTPTGER4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100516049-C | Antiangiogenic agent N2Synthesis of- (substituted arylmethyl) -3- (substituted phenyl) indazoles | YUNG SHIN PHARM IND CO LTD (CN) | 2009-07-22 | — | — | CN | disclosed |
| US-7514465-B2 | Synthesis of N2-(substituted arylmethyl)-3-(substituted phenyl)indazoles as novel anti-angiogenic agents | YUNG SHIN PHARM. IND. CO., LTD. (TW) | 2009-04-07 | — | — | US | disclosed |
| CN-1962640-A | Novel anti-angiogenic drug N2Synthesis of- (substituted arylmethyl) -3- (substituted phenyl) indazoles | YUNG SHIN PHARM IND CO LTD (CN) | 2007-05-16 | — | — | CN | disclosed |
| EP-1659115-A1 | Synthesis of substituted 2H-indazole derivatives as anti-angiogenic agents | Yung Shin Pharm. Ind. Co., Ltd. (TW) | 2006-05-24 | — | — | EP | disclosed |
| US-20060106032-A1 | Synthesis of N2 - (substituted arylmethyl) -3- (substituted phenyl) indazoles as novel anti-angiogenic agents | YUNG SHIN PHARM. IND. CO., LTD. (TW) | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106032-A1 | Synthesis of N2 - (substituted arylmethyl) -3- (substituted phenyl) indazoles as novel anti-angiogenic agents | FLT4, FLT1, KDR | F2RL3 611/4885CYP19A1 1664/4885SMN1; SMN2 2932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.