Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491428 | 0.85 | DHODH (0.42) | DHODHKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL4481851 | 0.83 | DHODH (0.62) | DHODHKDM4EALDH1A1NPSR1LMNA | |
| SCHEMBL2427298 | 0.75 | DHODH (0.41) | DHODHKDM4EALDH1A1NPSR1LMNA | |
| SCHEMBL3924341 | 0.75 | ESR1 (0.53) | DHODHMEN1KMT2A | |
| SCHEMBL12285138 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL27918631 | 0.73 | KDM4E (0.48) | DHODHKDM4EALDH1A1NPSR1LMNA | |
| SCHEMBL2867767 | 0.73 | MAPK14 (0.69) | KDM4EALDH1A1NPSR1LMNATDP1 | |
| SCHEMBL1289655 | 0.72 | DHODH (0.59) | DHODHKDM4EALDH1A1MAPTPLA2G2A | |
| SCHEMBL4482092 | 0.72 | PLA2G2A (0.60) | KDM4EALDH1A1NPSR1LMNAMAPT | |
| SCHEMBL29636809 | 0.72 | KDM4E (0.65) | DHODHKDM4EALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632845-B2 | 2-(p-oxyphenyl)-6-oxyquinolines, e.g., 2-(3-Fluoro-4-hydroxyphenyl)-4-phenylquinolin-6-ol; inflammatory bowel disease; Crohn's disease; anticarcinogenic agents; anticholesterol agents; antilipemic agents; cardiovascular diorders; osteoporosis; A lzheimer's disease; fertility; antiarthritic agents | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20060217399-A1 | Phenyl quinolines and their use as estrogenic agents | WYETH (US) | 2006-09-28 | — | — | US | disclosed |
| US-7084276-B2 | Phenyl quinolines and their use as estrogenic agents | WYETH (US) | 2006-08-01 | — | — | US | disclosed |
| EP-1628961-A1 | PHENYL QUINOLINES AND THEIR USE AS ESTROGEN RECEPTOR MODULATORS | Wyeth (US) | 2006-03-01 | — | — | EP | disclosed |
| US-20050009784-A1 | Phenyl quinolines and their use as estrogenic agents | WYETH | 2005-01-13 | — | — | US | disclosed |
| WO-2004103973-A1 | PHENYL QUINOLINES AND THEIR USE AS ESTROGEN RECEPTOR MODULATORS | WYETH (US) | 2004-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009784-A1 | Phenyl quinolines and their use as estrogenic agents | ESR1, GPER1, ESR2 | DHODH 2202/4885KDM4E 638/4885ALDH1A1 904/4885 |
| US-20060217399-A1 | Phenyl quinolines and their use as estrogenic agents | ESR1, GPER1, ESR2 | DHODH 2202/4885KDM4E 638/4885ALDH1A1 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.