Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.69 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.69 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.66 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.57 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480304 | 0.89 | HDAC6 (0.59) | FGFR1FGFR2FGFR3HDAC6CDK7 | |
| SCHEMBL4487092 | 0.89 | HDAC6 (0.64) | FGFR1FGFR2FGFR3HDAC6CDK7 | |
| SCHEMBL4490781 | 0.89 | HDAC6 (0.67) | FGFR1FGFR2FGFR3HDAC6GSK3B | |
| SCHEMBL4491952 | 0.86 | HDAC6 (0.56) | FGFR1FGFR2FGFR3HDAC6CDK7 | |
| SCHEMBL4493867 | 0.86 | HDAC6 (0.60) | FGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL4500056 | 0.84 | HDAC6 (0.55) | FGFR1FGFR2FGFR3HDAC6GSK3B | |
| SCHEMBL4493989 | 0.84 | HDAC6 (0.55) | FGFR1FGFR2FGFR3HDAC6AAK1 | |
| SCHEMBL4504597 | 0.84 | HDAC6 (0.57) | FGFR1FGFR2FGFR3HDAC6 | |
| SCHEMBL4479787 | 0.84 | FGFR1 (0.73) | FGFR1FGFR2FGFR3HDAC6AAK1 | |
| SCHEMBL4493801 | 0.83 | GSK3B (0.51) | FGFR1FGFR2FGFR3HDAC6AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |