Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497956 | 0.89 | GSK3B (0.52) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4504699 | 0.87 | GSK3B (0.56) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4480572 | 0.87 | FGFR1 (0.47) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4498346 | 0.87 | GSK3B (0.62) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4493797 | 0.86 | AAK1 (0.58) | GSK3BHDAC6GSK3AAAK1MAPK1 | |
| SCHEMBL4502518 | 0.86 | GSK3B (0.65) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4494390 | 0.84 | GSK3B (0.49) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4493014 | 0.83 | MAPK1 (0.53) | GSK3BHDAC6GSK3AFGFR1FGFR2 | |
| SCHEMBL4480768 | 0.83 | FGFR1 (0.69) | GSK3BHDAC6FGFR1FGFR2FGFR3 | |
| SCHEMBL4482990 | 0.83 | GSK3B (0.65) | GSK3BHDAC6GSK3AFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |