Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 5/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480696 | 0.91 | AAK1 (0.57) | AAK1GSK3BACHEGSK3ACYP1A2 | |
| SCHEMBL4505382 | 0.90 | CYP1A2 (0.58) | AAK1GSK3BGSK3ACYP1A2 | |
| SCHEMBL4479320 | 0.88 | AAK1 (0.64) | AAK1GSK3BACHEGSK3ACYP1A2 | |
| SCHEMBL4484072 | 0.86 | GSK3B (0.70) | AAK1GSK3BACHEGSK3ACYP1A2 | |
| SCHEMBL4495269 | 0.86 | AAK1 (0.75) | AAK1GSK3BGSK3A | |
| SCHEMBL4483758 | 0.85 | HDAC1 (0.67) | AAK1GSK3BACHEGSK3AFGFR1 | |
| SCHEMBL4486080 | 0.85 | GSK3B (0.66) | AAK1GSK3BACHEGSK3ACYP1A2 | |
| SCHEMBL4506175 | 0.84 | AAK1 (0.58) | AAK1GSK3BACHEGSK3AMAPK1 | |
| SCHEMBL4491665 | 0.84 | HDAC1 (0.67) | AAK1GSK3BACHEFGFR1FGFR2 | |
| SCHEMBL4483544 | 0.84 | AAK1 (0.75) | AAK1GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |