Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.64 |
| ▸ | GSK3B | P49841 | 7/20 | 0.56 |
| ▸ | ACHE | P22303 | 3/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485536 | 0.92 | HDAC6 (0.58) | AAK1GSK3BACHEGSK3ACYP1A2 | |
| SCHEMBL4486080 | 0.91 | GSK3B (0.66) | AAK1GSK3BACHEGSK3ACYP1A2 | |
| SCHEMBL4480795 | 0.88 | AAK1 (0.61) | AAK1GSK3BACHEGSK3ACYP1A2 | |
| SCHEMBL4484072 | 0.88 | GSK3B (0.70) | AAK1GSK3BACHEGSK3ACYP1A2 | |
| SCHEMBL4506175 | 0.88 | AAK1 (0.58) | AAK1GSK3BACHEGSK3AMAPK1 | |
| SCHEMBL4483758 | 0.87 | HDAC1 (0.67) | AAK1GSK3BACHEGSK3A | |
| SCHEMBL4491665 | 0.85 | HDAC1 (0.67) | AAK1GSK3BACHE | |
| SCHEMBL4488385 | 0.85 | GSK3A (0.71) | AAK1GSK3BGSK3A | |
| SCHEMBL4494322 | 0.85 | GSK3B (0.56) | AAK1GSK3BACHEGSK3AMAPK1 | |
| SCHEMBL4480696 | 0.84 | AAK1 (0.57) | AAK1GSK3BACHEGSK3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |