Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491749 | 0.91 | HDAC1 (0.64) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4502352 | 0.91 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4491665 | 0.91 | HDAC1 (0.67) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4493309 | 0.88 | HDAC6 (0.63) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4479320 | 0.87 | AAK1 (0.64) | AAK1ACHEGSK3BGSK3A | |
| SCHEMBL4494068 | 0.87 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4481656 | 0.86 | HDAC1 (0.85) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4498522 | 0.86 | HDAC1 (0.55) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4480795 | 0.85 | AAK1 (0.61) | AAK1FGFR1ACHEGSK3BFGFR2 | |
| SCHEMBL4488478 | 0.85 | HDAC1 (0.83) | HDAC1HDAC2HDAC8HDAC6AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |