Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27855818 | 0.93 | MAPT (0.50) | PARP1HDAC8HDAC6KMT2AESR1 | |
| SCHEMBL28832198 | 0.89 | DHODH (0.49) | PARP1HDAC8HDAC6KMT2AESR1 | |
| SCHEMBL44313 | 0.83 | PARP1 (0.61) | PARP1HDAC8HDAC6KMT2AESR1 | |
| SCHEMBL29397067 | 0.83 | PARP1 (0.61) | PARP1HDAC8HDAC6KMT2AESR1 | |
| SCHEMBL4188727 | 0.83 | PARP1 (0.61) | PARP1HDAC8HDAC6KMT2AESR1 | |
| SCHEMBL31316346 | 0.83 | PARP1 (0.61) | PARP1HDAC8HDAC6KMT2AESR1 | |
| SCHEMBL28884253 | 0.82 | PARP1 (0.55) | PARP1HDAC8HDAC6KMT2AESR1 | |
| SCHEMBL40429 | 0.82 | GPR17 (0.65) | PARP1HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL6904430 | 0.82 | PARP1 (0.59) | PARP1HDAC8HDAC6KMT2AESR1 | |
| SCHEMBL669300 | 0.82 | PARP1 (0.64) | PARP1HDAC8HDAC6KMT2AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4271674-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-11-08 | — | — | EP | disclosed |
| WO-2022225914-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-10-27 | — | — | WO | disclosed |
| CN-108553467-A | Improve the method for diaphragm function | 赛特凯恩蒂克公司 | 2018-09-21 | — | — | CN | disclosed |
| CN-107074808-A | It is used as the therapeutic compound of the acceptor inhibitor of orexin 1 | 希四克斯探索有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-105793238-A | Substituted benzamides and methods of use thereof | 基因泰克公司 | 2016-07-20 | — | — | CN | disclosed |
| CN-103502226-B | cycloalkenyl aryl derivatives for CETP inhibitors | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2015-08-19 | — | — | CN | disclosed |
| CN-103459369-B | Guanidine compound | ASTELLAS PHARMA INC | 2015-05-27 | — | — | CN | disclosed |
| CN-104395458-A | Improving resistance to skeletal muscle fatigue | CYTOKINETICS INC | 2015-03-04 | — | — | CN | disclosed |
| CN-104379597-A | Method for improving diaphragm function | CYTOKINETICS INC | 2015-02-25 | — | — | CN | disclosed |
| CN-104039149-A | Boron-containing small molecules | ANACOR PHARMACEUTICALS INC | 2014-09-10 | — | — | CN | disclosed |
| US-8735384-B2 | Amino heteroaryl compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-05-27 | — | — | US | disclosed |
| CN-103804358-A | Biaryl hydantoin derivate and preparation method, medicine composition and application thereof | SHANGHAI PHARMACEUTICAL GROUP CO LTD | 2014-05-21 | — | — | CN | disclosed |
| CN-103517910-A | Morpholine-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMA | 2014-01-15 | — | — | CN | disclosed |
| CN-103502226-A | Cycloalkenyl aryl derivatives for CETP inhibitors | CHONG KUN DANG PHARM CORP | 2014-01-08 | — | — | CN | disclosed |
| CN-103443105-A | Chroman-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMA | 2013-12-11 | — | — | CN | disclosed |
| US-20130040931-A1 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use | AMGEN INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-7629363-B2 | antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| CN-100345853-C | Pyrazolopyrimidine compound and method for producing the same | TANABE SEIYAKU CO (JP) | 2007-10-31 | — | — | CN | disclosed |
| CN-1269817-C | Dehalogenated compounds | DAIICHI SEIYAKU CO (JP) | 2006-08-16 | — | — | CN | disclosed |
| CN-1486315-A | Dehalogenated compounds | ��һ��������ҩ��ʽ���� | 2004-03-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040931-A1 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use | BACE1, BACE2, APH1B | PARP1 1194/4885HDAC8 4123/4885HDAC6 4319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.