Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | QPCT | Q16769 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494610 | 0.92 | KDM4E (0.52) | KDM4EGAARAD52TDP1GSK3B | |
| SCHEMBL4502734 | 0.90 | ALDH1A1 (0.55) | KDM4EGAAQPCTNAMPTALDH1A1 | |
| SCHEMBL4488444 | 0.87 | GSK3B (0.55) | KDM4EGAARAD52TDP1GSK3B | |
| SCHEMBL4503182 | 0.86 | AAK1 (0.55) | KDM4EGSK3BLMNAQPCTNAMPT | |
| SCHEMBL4487221 | 0.86 | HDAC1 (0.56) | KDM4EGAALMNAQPCTNAMPT | |
| SCHEMBL4502522 | 0.84 | HDAC1 (0.56) | KDM4EQPCTNAMPTHSD17B10ALDH1A1 | |
| SCHEMBL4480331 | 0.82 | GSK3B (0.61) | GSK3BCYP1A2ABL1BCR | |
| SCHEMBL4492112 | 0.82 | GSK3B (0.61) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL12886058 | 0.82 | HDAC6 (0.56) | KDM4ELMNAQPCTCYP1A2CYP3A4 | |
| SCHEMBL4492939 | 0.81 | GSK3B (0.60) | GSK3BHDAC1HDAC2HDAC8ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |