Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | QPCT | Q16769 | 2/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4502734 | 0.93 | ALDH1A1 (0.55) | HDAC1HDAC2HDAC8MAPTHDAC6 | |
| SCHEMBL4494610 | 0.89 | KDM4E (0.52) | MAPTLMNAQPCTNAMPTKMT2A | |
| SCHEMBL4503182 | 0.87 | AAK1 (0.55) | MAPTLMNAQPCTNAMPTALDH1A1 | |
| SCHEMBL4481640 | 0.86 | KDM4E (0.52) | HDAC1HDAC2HDAC8MAPTLMNA | |
| SCHEMBL4502522 | 0.86 | HDAC1 (0.56) | HDAC1HDAC2HDAC8MAPTHDAC6 | |
| SCHEMBL4493584 | 0.84 | HDAC1 (0.66) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4480272 | 0.84 | HDAC1 (0.66) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4485217 | 0.83 | HDAC1 (0.65) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL12886058 | 0.83 | HDAC6 (0.56) | HDAC1HDAC2HDAC8LMNAHDAC6 | |
| SCHEMBL4488444 | 0.82 | GSK3B (0.55) | HDAC1HDAC2HDAC8MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |