Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 10/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | HTT | P42858 | 6/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470067 | 0.76 | GAA (0.59) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL6471331 | 0.75 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL3523394 | 0.72 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL4542179 | 0.71 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL4537567 | 0.71 | MAPT (0.59) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL4542493 | 0.71 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL6115673 | 0.71 | CYP2C9 (0.59) | MAPTMEN1KMT2ANPSR1POLB | |
| SCHEMBL7827542 | 0.69 | GAA (0.77) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL4481461 | 0.69 | ALDH1A1 (0.56) | SMN1; SMN2MAPTNPSR1POLBKDM4E | |
| SCHEMBL4539932 | 0.68 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | claimed |
| US-7629363-B2 | antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| US-7067540-B2 | Substituted pyridinones | PHARMACIA CORPORATION (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058964-A1 | Substituted pyridinones | MAPK1, MAPK6, MAPK7 | SMN1; SMN2 1433/4885MAPT 2803/4885MEN1 4261/4885 |
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | SMN1; SMN2 1419/4885MAPT 2543/4885MEN1 3919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.