Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.57 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4486932 | 0.99 | CYP19A1 (0.65) | CYP19A1PKMKEAP1IDO1LMNA | |
| SCHEMBL3681880 | 0.88 | CYP19A1 (0.85) | CYP19A1PKMKEAP1IDO1LMNA | |
| SCHEMBL38660104 | 0.88 | CYP19A1 (0.85) | CYP19A1PKMKEAP1IDO1LMNA | |
| SCHEMBL151655 | 0.84 | KEAP1 (0.76) | CYP19A1KEAP1LMNASLC12A2SLC12A5 | |
| SCHEMBL5032445 | 0.83 | CYP19A1 (0.85) | CYP19A1PKMKEAP1LMNASLC12A2 | |
| SCHEMBL31339948 | 0.83 | CYP19A1 (0.85) | CYP19A1PKMKEAP1LMNASLC12A2 | |
| SCHEMBL4481323 | 0.82 | HDAC3 (0.55) | CYP19A1CA12CA9CYP1A2CYP3A4 | |
| SCHEMBL5952598 | 0.80 | KEAP1 (0.64) | CYP19A1PKMKEAP1LMNASLC12A2 | |
| SCHEMBL2492471 | 0.80 | KEAP1 (0.69) | CYP19A1KEAP1LMNASLC12A2SLC12A5 | |
| SCHEMBL4470901 | 0.79 | CYP19A1 (0.62) | CYP19A1PKMKEAP1IDO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215645-A1 | Amide derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2005-09-29 | — | — | US | claimed |
| US-7598418-B2 | Naphthalene-1-(sulfonamide or carboxamide) derivatives; e.g. N-Benzyl-5-{[(4-methylphenyl)sulfonyl]oxy}naphthalene-1-sulfonamide; protein kinase inhibitors sensitize cancer cells to radiotherapy or anticancer agents; side effect reduction | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2009-10-06 | — | — | US | disclosed |
| US-20050215645-A1 | Amide derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215645-A1 | Amide derivatives | OGG1, HDAC1, BCL2A1 | CYP19A1 552/4885PKM 2153/4885KEAP1 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.