SCHEMBL448261

SCHEMBL448261

N#Cc1ccnc(Br)c1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30295272 1.00
SCHEMBL27439362 0.78 CYP11B2 (0.44)
SCHEMBL29562545 0.77
SCHEMBL5700328 0.77
SCHEMBL20448774 0.77
SCHEMBL29500425 0.76 NPY5R (0.45)
SCHEMBL9792784 0.76 NPY5R (0.45)
SCHEMBL29598148 0.74 CLK4 (0.44)
SCHEMBL995799 0.74 CLK4 (0.44)
SCHEMBL931687 0.74 CYP1A1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 431 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479824-B2 Method for preparing ivosidenib and an intermediate thereof SERVIER PHARMACEUTICALS LLC (US) 2025-11-25 US claimed
CN-118580235-A Preparation method of lactam compound 正大天晴药业集团股份有限公司 2024-09-03 CN claimed
EP-4010331-B1 A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF SERVIER LAB (FR) 2023-10-04 EP claimed
CN-115724793-A Preparation method of 2-bromoisonicotinic acid nitrile 山西永津集团有限公司 2023-03-03 CN claimed
US-20230025411-A1 A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF SERVIER PHARMACEUTICALS LLC 2023-01-26 US claimed
EP-4010331-A1 A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF Les Laboratoires Servier (FR) 2022-06-15 EP claimed
WO-2021079380-A1 IMPROVED PROCESS FOR THE PREPARATION OF (2S)-N-{(1S)-1-(2-CHLOROPHENYL)-2-[(3,3-DIFLUOROCYCLOBUTYL)-AMINO]-2-OXOETHYL}-1-(4-CYANOPYRIDIN-2-YL)-N-(5-FLUOROPYRIDIN-3-YL)-5-OXOPYRROLIDINE-2-CARBOXAMIDE MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) 2021-04-29 WO claimed
WO-2021026436-A1 A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF AGIOS PHARMACEUTICALS, INC. (US) 2021-02-11 WO claimed
WO-2020127887-A1 PROCESS FOR THE PREPARATION OF AN INTERMEDIATE PRODUCT OF IVOSIDENIB SANDOZ AG (CH) 2020-06-25 WO claimed
EP-4747258-A2 COMPOUNDS, COMPOSITIONS, AND METHODS Tenvie Therapeutics, Inc. (US) 2026-05-27 EP disclosed
EP-3985001-B1 PHARMACEUTICAL COMPOSITION FOR USE IN TREATING A CANCER SERVIER LAB (FR) 2026-04-29 EP disclosed
US-12606564-B2 Adenosine receptor antagonist compounds ILDONG PHARMACEUTICAL CO., LTD. (KR) 2026-04-21 US disclosed
US-12552772-B2 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD SPRINGWORKS THERAPEUTICS, INC. (US) 2026-02-17 US disclosed
WO-2025262433-A1 N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS MISSION THERAPEUTICS LIMITED (GB) 2025-12-26 WO disclosed
US-20100093703-A1 SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-04-15 US disclosed
US-20100093703-A1 SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-04-15 US disclosed
WO-2009134392-A1 CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 VITAE PHARMACEUTICALS, INC. (US) 2009-11-05 WO disclosed
WO-2009017664-A1 CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1 VITAE PHARMACEUTICALS, INC. (US) 2009-02-05 WO disclosed
WO-2008099000-A2 SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-08-21 WO disclosed
US-6200978-B1 FOR PREVENTING OR TREATING INFLAMMATORY DISEASES SUCH AS ARTHRITIS, PSORIASIS, ASTHMA, OR INFLAMMATORY BOWEL DISEASE, DISORDERS OF RESPIRATORY FUNCTION, GASTROINTESTINAL DISORDERS SUCH AS FUNCTIONAL BOWEL DISEASE, AS ANALGESICS PFIZER INC. 2001-03-13 US disclosed