Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | METAP1 | P53582 | 4/20 | 0.49 |
| ▸ | METAP2 | P50579 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18606683 | 0.76 | L3MBTL1 (0.58) | L3MBTL1TDP1NPC1SMN1; SMN2HTT | |
| SCHEMBL12143473 | 0.74 | METAP1 (0.73) | L3MBTL1TDP1METAP1METAP2GRM5 | |
| SCHEMBL16370046 | 0.74 | L3MBTL1 (0.63) | L3MBTL1TDP1NPC1SMN1; SMN2HTT | |
| SCHEMBL20665658 | 0.74 | L3MBTL1 (0.54) | L3MBTL1TDP1NPC1SMN1; SMN2HTT | |
| SCHEMBL22883080 | 0.73 | KDM4E (0.62) | L3MBTL1TDP1NPC1SMN1; SMN2LMNA | |
| SCHEMBL11593238 | 0.73 | KMT2A (0.63) | TDP1NPC1SMN1; SMN2HTTLMNA | |
| SCHEMBL896765 | 0.71 | L3MBTL1 (0.48) | L3MBTL1NPC1SMN1; SMN2HTTLMNA | |
| SCHEMBL11036761 | 0.70 | KDM4E (0.68) | L3MBTL1TDP1NPC1SMN1; SMN2HTT | |
| SCHEMBL9489007 | 0.70 | L3MBTL1 (0.65) | L3MBTL1TDP1NPC1SMN1; SMN2HTT | |
| SCHEMBL1442798 | 0.70 | METAP1 (0.68) | L3MBTL1TDP1LMNAMETAP1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066655-A2 | PYRIDINYL-PYRIMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008028935-A2 | PYRIDINYL-PYRIMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2008-03-13 | — | — | WO | disclosed |