Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480304 | 0.90 | HDAC6 (0.59) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4500986 | 0.90 | HDAC6 (0.76) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4493689 | 0.88 | HDAC6 (0.62) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4492649 | 0.88 | HDAC6 (0.67) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4500503 | 0.88 | FGFR2 (0.58) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4489751 | 0.85 | HDAC6 (0.61) | HDAC6FGFR1FGFR2FGFR3GSK3B | |
| SCHEMBL4485588 | 0.85 | HDAC6 (0.63) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4485646 | 0.85 | HDAC6 (0.70) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4498018 | 0.85 | FGFR2 (0.53) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4498046 | 0.85 | HDAC6 (0.57) | HDAC6FGFR1FGFR2FGFR3FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |