Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.70 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 3/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489751 | 0.94 | HDAC6 (0.61) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4500503 | 0.89 | FGFR2 (0.58) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4491728 | 0.87 | FGFR1 (0.61) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4480304 | 0.87 | HDAC6 (0.59) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4498043 | 0.87 | GSK3B (0.61) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4495251 | 0.87 | HDAC6 (0.70) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4488340 | 0.87 | HDAC6 (0.66) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4483456 | 0.85 | HDAC6 (0.61) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4492924 | 0.85 | HDAC6 (0.70) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4558929 | 0.85 | HDAC6 (0.74) | HDAC6FGFR2FGFR3FGFR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |