Sugi Predict

Sugi Predict / Compounds / SCHEMBL4483540

SCHEMBL4483540

SCHEMBL4483540

CC(C)NC(=O)N(S)c1ccc2[nH]c(-c3ccccc3-c3nc4cc(NC(=O)N(S)C(C)C)ccc4[nH]3)nc2c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 3/20 0.40
▸ RXFP1 Q9HBX9 1/20 0.40
▸ KDM4E B2RXH2 8/20 0.38
▸ SMN1; SMN2 Q16637 3/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ MEN1 O00255 4/20 0.37
▸ KMT2A Q03164 4/20 0.37
▸ ALDH1A1 P00352 4/20 0.37
▸ LDLR P01130 1/20 0.37
▸ MAPT P10636 2/20 0.37
▸ HTT P42858 1/20 0.37
▸ NPC1 O15118 2/20 0.36
▸ RAB9A P51151 2/20 0.36
▸ THRB P10828 2/20 0.35
▸ POLB P06746 3/20 0.35
▸ HPGD P15428 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ ADORA2A P29274 1/20 0.35
▸ RECQL P46063 1/20 0.34
▸ ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4508672 0.80 NR2E3 (0.42) TP53RXFP1KDM4ESMN1; SMN2MEN1
SCHEMBL4496033 0.79 TP53 (0.38) TP53RXFP1KDM4ESMN1; SMN2MEN1
SCHEMBL4483537 0.74 KDM4E (0.54) TP53RXFP1KDM4ESMN1; SMN2MAPK1
SCHEMBL4496122 0.72 KDM4E (0.61) TP53KDM4ESMN1; SMN2MEN1KMT2A
SCHEMBL4496201 0.72 TP53 (0.49) TP53RXFP1KDM4ESMN1; SMN2MAPK1
SCHEMBL4496830 0.67 PTPRC (0.53) TP53RXFP1KDM4ESMN1; SMN2MAPK1
SCHEMBL4483534 0.67 ALDH1A1 (0.43) TP53RXFP1KDM4ESMN1; SMN2MAPK1
SCHEMBL4480173 0.67 DGAT1 (0.60) TP53RXFP1KDM4ESMN1; SMN2MAPK1
SCHEMBL2242067 0.66 NR2E3 (0.60) TP53KDM4ESMN1; SMN2MAPK1MEN1
SCHEMBL4507119 0.64 COMT (0.67) KDM4EMEN1KMT2AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7482373-B2 Bis-benzimidazoles and related compounds as potassium channel modulators ICAGEN, INC. (US) 2009-01-27 — — US disclosed
US-20070027200-A1 Bis-benzimidazoles and related compounds as potassium channel modulators ICAGEN, INC. (US) 2007-02-01 — — US disclosed
US-7132439-B2 Bis-benzimidazoles and related compounds as potassium channel modulators ICAGEN, INC. (US) 2006-11-07 — — US disclosed
US-20040029925-A1 Bis-benzimidazoles and related compounds as potassium channel modulators ICAGEN, INC. (US) 2004-02-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070027200-A1 Bis-benzimidazoles and related compounds as potassium channel modulators KCNJ2, KCNA3, KCNB2 TP53 3963/4885RXFP1 4383/4885KDM4E 488/4885
US-20040029925-A1 Bis-benzimidazoles and related compounds as potassium channel modulators KCNJ2, KCNA3, KCNB2 TP53 3963/4885RXFP1 4383/4885KDM4E 488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.