Sugi Predict

Sugi Predict / Compounds / SCHEMBL4484637

SCHEMBL4484637

SCHEMBL4484637

N#Cc1c(Nc2ccc3c(c2)CCC3)sc(C(=O)c2ccccn2)c1N

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.51
▸ ALDH1A1 P00352 5/20 0.51
▸ GAA P10253 1/20 0.51
▸ HPGD P15428 2/20 0.49
▸ MAPK1 P28482 2/20 0.49
▸ HTT P42858 1/20 0.49
▸ POLB P06746 3/20 0.47
▸ LMNA P02545 2/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ ALOX12 P18054 1/20 0.47
▸ MELK Q14680 5/20 0.40
▸ RAB9A P51151 2/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ DHODH Q02127 1/20 0.38
▸ CDK5 Q00535 1/20 0.38
▸ CDK5R1 Q15078 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4480522 0.86 MAPT (0.48) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4477411 0.83 MAPT (0.57) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4476868 0.81 MAPT (0.57) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4475075 0.80 ALDH1A1 (0.59) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4469431 0.78 MAPT (0.55) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4472300 0.77 MELK (0.66) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4500686 0.77 ALDH1A1 (0.46) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4476854 0.76 MELK (0.49) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4474711 0.76 MELK (0.47) MAPTALDH1A1GAAHPGDMAPK1
SCHEMBL4487251 0.75 LMNA (0.54) MAPTALDH1A1GAAHPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A MAPT 3524/4885ALDH1A1 802/4885GAA 77/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A MAPT 3524/4885ALDH1A1 802/4885GAA 77/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.